DEMOPULOS, Gregory A.,DUDLER, Thomas,SCHWAEBLE, Hans-Wilhelm,CUMMINGS, W. Jason,TJOELKER, Larry W.,WOOD, Christi L.,YABUKI, Munehisa
申请号：
PE2019000261
公开号：
PE20190389A1
申请日:
2017.07.31
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to a single monoclonal antibody or a part polymerized into the antibody, which is specifically connected to the SERINA protein domain of masp-3 human, including: (a) a variable heavy chain region composed of hc-cdr1 determined as SEQ ID No: 84 (gkwie)；A hc-cdr2 is determined as SEQ ID No: 86, etc.； hc-cdr3 is determined as SEQ ID No: 88, etc.； and a variable light chain region, including a lc-cdr1, is determined as SEQ ID No: 142, etc., and inhibits the startup of plug-in alternative paths. The characteristics are at least one or more of the following: (a) inhibition Type D maturity； no support for masp-1 (SEQ ID No: 8)；Alternative pathways are inhibited in an animal mammal from 1:1 to 2.5:1 (target mas-p3 to mAb). It also refers to cells that represent antibodies or alliance fragments of the provided antigen, as well as related vectors and antibodies or detectable alliance fragments of the antigen. These antibodies can be used to treat various diseases, such as advanced mumps hemoglobin, age-related macular degeneration, arthritis, asthma and so on.Se refiere a un anticuerpo monoclonal aislado o fragmento de union al antigeno del mismo que se une especificamente al dominio de proteasas de serina de MASP-3 humana que comprende: (a) una region variable de cadena pesada que comprende un HC-CDR1 establecido como SEQ ID NO: 84 (GKWIE)； un HC-CDR2 establecido como SEQ ID NO: 86, entre otros； HC- CDR3 establecido como SEQ ID NO: 88； y una region variable de cadena ligera que comprende un LC-CDR1 establecido como SEQ ID NO: 142, entre otros e inhibe la activacion de la via alternativa del complemento； y se caracteriza por al menos una o mas de las siguientes propiedades: (a) inhibe la maduracion pro-factor D； no se adhiere al MASP-1 humano (SEQ ID NO: 8)； inhibe la via alternativa en una proporcion molar de 1:1 a 2,5:1 (objetivo MAS-P3 a mAb) en un animal mamifero, entre otros. Tambien se refiere a celulas que expresan los anticuerpos o fragmentos de union al a
