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Method for obtaining a natural mixture of conjugated estrogens impoverished phenolic components in urine
专利权人:
ABBOTT PRODUCTS GMBH
发明人:
RASCHE HEINZ-HELMER,RUPP OLAF
申请号:
NO20042761
公开号:
NO331790B1
申请日:
2004.06.30
申请国别(地区):
NO
年份:
2012
代理人:
摘要:
Procedure for obtaining extracts a natural mixture of conjugated oestrogens from Mare's urine Prenadas.The extracts obtained in accordance with this Pharmaceutical Specification in terms of the minizaci u00f3n conjugated oestrogens and oestrogen concentration using urine free even Aged and / or stored or transported at elevated temperatures.Obtaining extracts containing a mixture of conjugated oestrogens from Mare's urine Prenadas extraction is performed by Fixed phase on semipolares adsorbent Resins.Claim 1: procedure for obtaining a natural mixture of conjugated oestrogens in the impoverished phenolic components from urine, the urine of mares Prenadas), in which a Liquid Uranus, eventually formed a Free mucila urinous Liquid substances Ginosas and solidA Concentrated liquid or a urinous this retained urine Concentrated by Filtration of this urinous Liquid Membrane is contacted with a sufficient quantity of adsorbent Resin for the adsorption of the polymer mixture of conjugated estrogens contained in urinous Liquid,Urinous remnant and separates from the liquid Resin Polymer adsorbent loaded with the mixture of conjugated oestrogens, (b) the polymer adsorbent Resin loaded with the mixture of conjugated oestrogens is washed with washing Water to alkaline pH of at least 21 0,And (c) The washed Resin adsorbent is contacted with a sufficient quantity of liquid eluent for the Desorption of the adsorbed mixture of conjugated oestrogens, constituted the liquid eluent by an organic Solvent miscible with water, selected from the Group comprising ethersAlcanoles Lower and Lower aliphatic ketones are miscible with water or a mixture of Organic Solvent miscible with water, with water alkalinized eventually, separating the adsorbent Resin eluate contains a natural blend of conjugated estrogens, which eventually concent RaWherein the operating stages (b) and (c) scrubbing is carried out, during which the Resin Polymer adsorbent loaded with the mixture of conjugated oestrogens is
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