HANSEN DENNIS JUL,ROSENBOHM CHRISTOPH,MELDGAARD MICHAEL
申请号:
IN201847011528
公开号:
IN201847011528A
申请日:
2018.03.28
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
ABSTRACT OLIGONUCLEOTIDE CONJUGATION PROCESS The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.