A method for automatically refilling a syringe for a powered angiographic injector arrangement, said method comprising:completing a first injection via the powered angiographic injector arrangement sensing a volume of fluid remaining in a chamber of said syringe following the first injectionproviding a fluid reservoir in communication with said chamberreceiving user input associated with a subsequent injection via said powered angiographic injector arrangement, said user input comprising a safety parameter for the subsequent injection selected from the group consisting of maximum injection volume, maximum flow rate, maximum pressure, and rise timedetermining a preset volume of fluid necessary for the subsequent injection based on the user inputcomparing said volume remaining in said chamber with said preset volume of fluid andeither(a) advancing a plunger within said chamber of said syringe to perform the subsequent injection if said preset volume of fluid is equal to or less than the volume of fluid remaining in said chamber, or(b) automatically retracting a plunger to a predetermined position within said chamber of said syringe to draw fluid from the fluid reservoir into the chamber if said preset volume of fluid is greater than the volume of fluid remaining in said chamber.