GUTIERREZ, Gabriel M.,KOTRAIAH, Vinayaka,PANNUCCI, James,AYALA, Ramses
申请号:
AU2018410849
公开号:
AU2018410849A1
申请日:
2018.02.28
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.