INDUSTRY-ACADEMIC COORPERATION FOUNDATION DAEGU HAANY UNIVERSITY
发明人:
KIM, Hee Young,김희영,YANG, Chae Ha,양채하
申请号：
KRKR2018/001371
公开号：
WO2018/143685A1
申请日:
2018.02.01
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to a patch composition for reducing blood pressure and, more particularly, to a patch composition comprising an agonist selected from the group consisting of an agonist of transient receptor potential cation channel subfamily V member 1 (TRPV1) and an agonist of transient receptor potential cation channel subfamily A member 1 (TRPA1) as an effective ingredient for reducing blood pressure, a patch coated with the patch composition, and a method of using the patch. Containing an agonist selected from the group consisting of an agonist of TRPV1 and an agonist of TRPA1, the patch composition of the present invention can stimulate C-fibers in the median nerve inside the wrist to effectively reduce blood pressure caused by hypertension. Because the above-mentioned effect can be elicited by contacting a patch composition with the skin, the use of the patch composition or patch of the present invention has the advantage of reducing a blood pressure very conveniently and safely, compared to preexisting oral drugs. In addition, capsaicin or mustard oil rather than expensive compounds can be used as the agonist, which enjoys the advantage of providing the patch at very inexpensive cost.La présente invention concerne une composition de timbre transdermique qui permet de faire baisser la pression artérielle et, plus particulièrement, une composition de timbre transdermique comprenant comme principe actif un agoniste sélectionné dans le groupe constitué par un agoniste du récepteur TRPV1 (membre 1 de la sous-famille V du canal cationique à potentiel de récepteur transitoire) et un agoniste du récepteur TRPA1 (membre 1 de la sous-famille A du canal cationique à potentiel de récepteur transitoire) en tant que principe actif pour faire baisser la tension artérielle, un timbre transdermique recouvert de la composition dudit timbre, ainsi quune méthode dutilisation de celui-ci. Selon la présente invention, la composition de timbre transdermique, contenant
