A single use syringe with locking needle safety cover comprising a plunger arm, plunger tip, syringe body, tip retaining sleeve, and locking needle safety cover is disclosed. The tip retaining arms grasp the plunger tip. After the plunger arm is pulled backwards, sleeve ribs of the tip retaining sleeve prevent the tip retaining sleeve from moving in a forward direction. As the plunger arm is pushed forward, the tip retaining arms are no longer surrounded by the tip retaining sleeve and the tip retaining arms move outwards and release the plunger tip. After the plunger tip has been released from the plunger arm, the plunger tip and the plunger arm cannot be reconnected and the single use syringe with locking needle safety cover cannot be reused. When rotated, the locking needle safety cover traps the injection needle thereby preventing retraction of the locking needle safety cover.
