A single use syringe with plunger arm safety cover comprising a plunger arm, plunger tip, syringe body, and tip retaining sleeve is disclosed. The tip retaining sleeve surrounds tip retaining arms of the plunger tip allowing the tip retaining arms to grasp the plunger arm. After the plunger arm is pulled backwards, sleeve ribs prevent the tip retaining sleeve from moving in a forward direction. As the plunger arm is pushed forward, the tip retaining arms are no longer surrounded by the tip retaining sleeve and the tip retaining arms move outwards and release the plunger tip. After the plunger tip has been released from the plunger arm, the plunger tip and the plunger arm cannot be reconnected and the single use syringe cannot be reused. The plunger arm is removed from the syringe body and locked onto a guide lock and covers the needle tip.
