POLYNUCLEOTIDES PERMETTANT L'EXPRESSION ET LA SECRETION D'UN PSEUDO-VIRUS RECOMBINE CONTENANT DES EPITOPES ETRANGERS, PRODUCTION ET UTILISATION DE CES POLYNUCLEOTIDES
INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE;INSTITUT PASTEUR
发明人:
申请号：
EP08804169.4
公开号：
EP2198020B1
申请日:
2008.09.12
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.
