Polynucleotides that allow the expression and secretion of recombinant pseudoviruses containing foreign epitopes, their production and use

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专利权人:

アンスティテュ・パストゥール;アンスティテュ、ナショナル、ド、ラ、サント、エ、ド、ラ、ルシェルシュ、メディカル（アンセルム）

发明人:

デン、チャン,マリー‐ルイーズ、ミシェル

申请号：

JP2010524517

公开号：

JP5710254B2

申请日:

2008.09.12

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/