INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);INSTITUT PASTEUR;INST NAT SANTE RECH MED
发明人:
DENG QIANG,MICHEL MARIE-LOUISE
申请号：
AU2008297093
公开号：
AU2008297093B9
申请日:
2008.09.12
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.
