Nowe chiralne N-acylo-5,6,7(8-podstawione)-tetrahydro- [1,2,4]triazolo[4,3-a]pirazyny jako selektywni antagoniści receptora NK-3, kompozycja farmaceutyczna i sposoby stosowania w zaburzeniach, w których pośredniczy receptor NK-3

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专利权人:

OGEDA S.A.

发明人:

HOVEYEDA, HAMID,DUTHEUIL, GUILLAUME,FRASER, GRAEME,ROY, MARIE-ODILE,EL BOUSMAQUI, MOHAMED,BATT, FRÉDÉRIC

申请号：

PL12766991

公开号：

PL2763992T3

申请日:

2012.10.03

申请国别(地区):

PL

年份:

2016

代理人:

摘要：

The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

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