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以唑基取代的吡啶化合物
专利权人:
LTD.;TAISHO PHARMACEUTICAL CO.
发明人:
TANAKA, HIROAKI,田中宏明,BOHNO, AYAKO,坊野绫子,坊野綾子,HAMADA, MAKOTO,滨田诚,濱田誠,ITO, YUJI,伊藤勇次,KOBASHI, YOHEI,小桥阳平,小橋陽平,KAWAMURA, MADOKA,川村円
申请号:
TW106104780
公开号:
TW201741294A
申请日:
2017.02.14
申请国别(地区):
TW
年份:
2017
代理人:
摘要:
The present invention provides a compound represented by formula [I'], which has the effect of inhibiting an enzyme which produces 20-HETE, or a pharmaceutically acceptable salt thereof. (In formula [I']: the structure represented by formula [III] is any one of the structures represented by formulae [IV]; R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3 alkanediyl, or formula -O-CH2CH2-; ring A represents (a) a substituted C4-6 cycloalkyl, (b) a nitrogen atom-containing, substituted, 4- to 6-membered, and saturated heterocyclyl, (c) a substituted phenyl, (d) a substituted pyridyl, (e) a substituted 2,3-dihydrobenzofuran, (f) an oxygen atom-containing, 4- to 6-membered, and saturated heterocyclyl, etc.).本發明為提供一種具有產生20-HETE之酵素的阻礙作用之下述式[I’]所示化合物或其製醫藥上可被許可的鹽。(上述式[I’]中,下述式[III]所示結構表示下述式群[IV]中任一結構R1表示氫原子、氟原子、甲基等;R2、R3及R4為獨立表示氫原子、氟原子或甲基;W表示單鍵、C1-3烷烴二基或式-O-CH2CH2-;環A表示(a)被取代之C4-6環烷基、(b)被取代之含有氮原子的4至6員飽和之雜環基、(c)被取代之苯基、(d)被取代之吡啶基、(e)被取代之2,3-二氫苯並呋喃、(f)含有氧原子的4至6員飽和之雜環基等)。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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