Aqueous Pharmaceutical composition containing a Therapeutic Agent and a biologic guanidine and guanidine derivative or an injection that includes the composition.
The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection, particularly an intravitreal injection. The composition includes a biologic therapeutic agent (e.g., an isolated monoclonal antibody that specifically binds to a C5 protein) that tends to raise the viscosity of the composition and a guanidine and/or guanidine derivative (e.g., L-arginine) that tends to lower the viscosity of the composition.La presente invención se refiere a una composición acuosa adecuada para inyección ocular conformada por un agente terapéutico biológico y una guanidina y/o derivados de guanidina, con una viscosidad final >； 10 cP.
