The present invention describes a kind of preparation method of Eliquis and is encapsulated in porous carrier or hot-melt extruded using the present invention with amorphous form. Eliquis the is prepared or unbodied dispersion of formation can be used to treat or prevent thromboembolic events in pharmaceutically acceptable or solid solution form and pharmaceutically acceptable effect. The invention further relates to a kind of pharmaceutical composition, containing amorphous Eliquis with being encapsulated in porous carrier and hot-melt extruded method.