Gowri Dorairaju,Anthony E. Listro,David R. Worthen
申请号：
US13399203
公开号：
US20120201865A1
申请日:
2012.02.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A hot-melt extruded composition is disclosed that includes about 20-80% wt. of a plant-derived phenolic material about 20-85% wt. of one or more edible or bioerodible excipients about 0-40% wt. of a surface active material about 0-40% wt. of an oral absorption enhancer and about 0-10% wt. of one or more pharmaceutical or food grade additives. The composition has been hot-melt extruded at a temperature substantially below the melting point of the plant-derived phenolic material to produce a hot-melt extruded composition wherein substantial degradation of the plant-derived phenolic material has not occurred.
