This invention disclosed a composition of the algal extracts containing C-phycocyanin. This composition not only effectively inhibit the growth of oral pathogens including Porphyromonathes gingivalis and Actinobacillus actinomycetemcomitans, but also reduce the inflammation caused by those pathogens. Therefore, the phenomenon of alveolar bone loss in periodontal patients is mitigation, achieving the effect of prevention and treatment of periodontal disease.本發明提供一種含有藻藍蛋白之藻類萃取物的組合物,能有效抑制口腔病原菌包括牙齦卟啉單胞菌(Porphyromonas gingivalis)和伴放線桿菌(Actinobacillus actinomycetemcomitans)的生長,並降低該病原菌所造成的發炎反應,使牙周病患者的齒槽骨流失現象減緩,而達到預防及治療牙周病的效果。