The present invention relates to use of an apolipoprotein A-1 (ApoA-1) polypeptide or its variant or mimetic peptide, or a vector encoding the same, or an agent that enhances endogenous ApoA-1 level, for promoting bone formation. In particular, the present invention is applicable to treatment of bone diseases or conditions, where bone formation is desired, such as bone loss diseases e.g. osteoporosis, or bone fracture.本發明係有關於一種脂蛋白元A-1(ApoA-1)多肽或其變異體或模擬肽、或編碼該等肽之載體、或增進內源ApoA-1含量之藥劑劑用於促進骨生成之用途。具體而言，本發明係可應用於治療需要骨生成之骨疾病或症狀，例如，骨流失疾病(如骨質疏鬆)或骨折。
