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METHODS FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS AND BONE-RELATED DISEASES
专利权人:
发明人:
ROBERT J. PIGNOLO
申请号:
US14682892
公开号:
US20150209407A1
申请日:
2015.04.09
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present disclosure is directed to the identification that R-Spondin-1 (RSpo1) acts as a positive regulator of bone formation. Accordingly, the presently disclosed subject matter provides methods for treating and/or preventing osteoporosis or bone-related disorders, including administering a pharmaceutical composition of a therapeutically effective amount of an R-Spondin (RSpo) agonist, e.g., an RSpo protein or functional fragment thereof, peptidomimetic, nucleic acid, small molecule, or other drug candidate, to a subject, e.g., a mammal. In one exemplary embodiment, the RSpo agonist is a therapeutic vector including a nucleic acid molecule encoding RSpo protein or a functional fragment thereof. The presently disclosed subject matter also provides methods for diagnosing osteoporosis and other bone-related disorders using RSpo as a marker, as well as screening methods for identifying other proteins that are involved in bone formation.
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