PROBLEM TO BE SOLVED: To provide a Tie2 activating agent, a neovascularization inhibitory agent, a blood vessel maturation agent, a blood vessel normalization agent, and a blood vessel stabilization agent, a claudin-5 production promoting agent, a lymphatic vessel stabilization agent, an eNOS production promoting agent, a blood vessel expansion agent, and a platelet aggregation inhibitory agent, and a pharmaceutical composition, which have high safety and have excellent Tie2 activating action, neovascularization inhibitory action, blood vessel maturation action, blood vessel normalization action, and blood vessel stabilization action, claudin-5 production promoting action, lymphatic vessel stabilization action, eNOS production promoting action, blood vessel expansion action, and platelet aggregation inhibitory action.SOLUTION: The present invention provides an endothelial nitric oxide synthase promoting agent, containing piperine.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】優れたＴｉｅ２活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、血管の安定化作用、クローディン－５産生促進作用、リンパ管の安定化作用、ｅＮＯＳ産生促進作用、血管拡張作用、及び血小板凝集抑制作用を有する安全性の高いＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、血管の安定化剤、クローディン－５産生促進剤、リンパ管の安定化剤、ｅＮＯＳ産生促進剤、血管拡張剤、及び血小板凝集抑制剤、並びに医薬品組成物の提供。【解決手段】ピペリンを含有する血管内皮型一酸化窒素合成酵素産生促進剤である。【選択図】なし
