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SUSTAINED RELEASE FORMULATION OF METFORMIN AND METHOD FOR PREPARING SAME
专利权人:
发明人:
申请号:
EP15850079.3
公开号:
EP3207945A1
申请日:
2015.07.21
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to a gastric-retention type sustained-release formulation of metformin as an insulin-independent diabetic agent, and a preparation method thereof. More specifically, the present invention relates to a gastric-retention type sustained-release formulation, which can effectively control drug release even with a small amount of a polymer by forming a sustained-release granulated material, which comprises granules containing metformin or a pharmaceutically acceptable salt thereof and a swellable polymer, and a water-insoluble coated on the surface of the granules and also can allow a tablet containing the drug to swell rapidly at an early stage by formulating via mixing of a superdisintegrant, which is capable of controlling the speed of gelation forming hydrogels, with the granulated material and a preparation method thereof
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