Park, Jun Hong,Lee, Ji Eun,Kim, Yu Jeong,Lyu, Chun Seon,Seo, Hyuk Seong,Oh, Tack Oon,Jeon, Eun Kyung,Han, Sung Kyun
申请号：
AU2015331250
公开号：
AU2015331250A1
申请日:
2015.07.21
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates to a gastric-retentive sustained release formulation of metformin, which is a non-insulin-dependent diabetes mellitus medicine, and a method for preparing the same. More particularly, the present invention relates to a gastric-retentive sustained release formulation, and a method for preparing the same, in which a sustained release granular product including a granule comprising metformin or a pharmaceutically acceptable salt thereof and a swellable polymer is produced, a water-insoluble polymer film being coated on the granule surface, and thus the release of drug can be effectively controlled while using a small quantity of the polymer, and the granular product is mixed and formulated with a superdinsintegrant which controls the gelation velocity to produce a hydrogel so that a tablet comprising the drug can be quickly swelled in the early stage.
