Jun Hong PARK,Ji Eun LEE,Yu Jeong KIM,Chun Seon LYU,Hyuk Seong SEO,Tack Oon OH,Eun Kyung JEON,Sung Kyun HAN
申请号：
US15516329
公开号：
US20170304208A1
申请日:
2015.07.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a gastric-retention type sustained-release formulation of metformin as an insulin-independent diabetic agent, and a preparation method thereof. More specifically, the present invention relates to a gastric-retention type sustained-release formulation, which can effectively control drug release even with a small amount of a polymer by forming a sustained-release granulated material, which comprises granules containing metformin or a pharmaceutically acceptable salt thereof and a swellable polymer, and a water-insoluble coated on the surface of the granules； and also can allow a tablet containing the drug to swell rapidly at an early stage by formulating via mixing of a superdisintegrant, which is capable of controlling the speed of gelation forming hydrogels, with the granulated material； and a preparation method thereof.
