Chang, Jong Wook,Kim, Dal-Soo,Yang, Yoon-Sun,Oh, Won Il
申请号：
AU2012216643
公开号：
AU2012216643A1
申请日:
2012.08.30
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012216643A120120920.pdf#####ABSTRACT The present invention provides a gene therapy composition for transferring one of a therapeutical gene, a maker gene, or a mixture thereof to a cell that expresses interleukin8(IL-8) or GRO-a and induces tropism of mesenchymal stem cells isolated from umbilical cord 5 blood and/or the me3enchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Also provided is a composition for treating disease related to a cell expressing IL-8 or GRO-a, that is, a brain tumor in gene therapy, by using UCB-MSCs. Also provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain ) tumor treatment progression by using UCB-MSCs. Also provided is a composition for detecting a cell, wherein the composition includes mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells, wherein the cell expresses at least one of IL-8 and GRO-a, wherein the cell is not a cancer cell, and wherein the mesenchymal stem cells isolated from umbilical cord blood 5 and/or the mesenchyrnal stem cells expanded from said mesenchymal stem cells are labeled with a detectable marker.
