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Method for the preparation of immunoglobulins
专利权人:
Instituto Grifols; S.A.
发明人:
Pere Ristol Debart,Salvador Grancha Gamon,Juan Ignacio Jorquera Nieto,Maria Mercedes Faro Tomas,Nuria Jorba Grifols
申请号:
US15276544
公开号:
US10358462B2
申请日:
2016.09.26
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention relates to a method for the preparation of a solution of immunoglobulins based on an initial solution of immunoglobulins with a purity greater than or equal to 96% in the presence of a polyether or polymer of glycol, characterized in that it comprises the steps of: a) adding caprylic acid or salts of the same to the initial solution; b) adjusting the pH of the solution obtained in step a); c) incubating the solution obtained in step b) for the time and at a temperature necessary for the inactivation of enveloped viruses; d) performing a step of ultrafiltration/diafiltration on the solution obtained in step c).
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