PROBLEM TO BE SOLVED: To provide a method for creating a model animal useful for evaluating a prevention or improvement effect and a salty taste enhancer or the like, to deterioration in responsiveness of a salty taste to a medicament, quasi-drug, and food and drink in which the responsiveness of a salty taste is deteriorated and/or an epithelial sodium channel is inhibited.SOLUTION: There is provided the method for creating a model animal with deteriorated responsiveness of a salty taste and the model animal in which the epithelial sodium channel of a taste bud is inhibited, including a step of developing hypertension to a non-human animal according to a human hypertension development mechanism.COPYRIGHT: (C)2013,JPO&INPIT【課題】塩味応答性が低下及び/又は上皮型ナトリウムチャネルが阻害されている、医薬、医薬部外品、飲食品等に対する塩味応答性低下の予防又は改善効果及び塩味増強剤等を評価するのに有用なモデル動物の作製方法を提供する。【解決手段】ヒト高血圧症発症機構に即して、非ヒト動物に高血圧を発症させる工程を含む、塩味応答性が低下しているモデル動物及び味蕾の上皮型ナトリウムチャネルが阻害されたモデル動物の作製方法。【選択図】なし
