Novel sodium channel inhibitor compound preparation method thereof and pharmaceutical composition for prevention or treatment of sodium channel related diseases containing the same as an active ingredient
EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION;이화여자대학교 산학협력단
发明人:
PARK HEA YOUNG,박혜영,YUNE TAE YOUNG,윤태영,OH JUNG AE,오정애
申请号：
KR1020180050511
公开号：
KR1020190126525A
申请日:
2018.05.02
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a novel sodium channel inhibiting compound, a method for producing the same, and a pharmaceutical composition for preventing or treating a sodium channel-related disease by including the same. According to the present invention, the novel sodium channel inhibiting compound is capable of inhibiting sodium channels excellently and, in particular, is a compound having excellent inhibitory activity on Nav 1.7 channel. As a pharmaceutical composition or health functional food composition containing the above as active ingredients, the present invention has beneficial effects capable of preventing, alleviating or treating sodium channel-related diseases such as pain disorders associated with sodium channel activity like Nav 1.7 channel-related diseases, specifically neuropathic pain, spontaneous provoked pain, paroxysmal extreme pain disorder, erythromelalgia, or erythromelalgia pain. The compound is represented by chemical formula 1.본 발명은 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 소듐채널 저해 화합물은 소듐채널을 우수하게 저해할 수 있고, 특히 Nav 1.7채널 억제활성이 우수한 화합물인 바, 이를 유효성분으로 함유하는 약학적 조성물 또는 건강기능식품 조성물로서, 소듐채널 관련 질환, 예를 들어 소듐채널의 활성과 관련한 통증 질환, 예를 들어 Nav 1.7채널 관련질환, 예를 들어, 신경병증성 통증(Neuropathic pain), 자발통증(spontaneous provoked pain), 발작적 통증 질환(paroxysmal extreme pain disorder), 홍색사지통증(erythromelalgia), 또는 홍반통증과 같은 질환을 예방, 개선, 또는 치료할 수 있는 유용한 효과가 있다.
