Pirazin compounds cabonil imino 2 - - - - - 1,3,8 triaza spiro [4.Deccan] - 5 - substituted,Blockers of the epithelial sodium channel (ENAC)； Pharmaceutical composition that includes； method of prevention or treatment； and its use to treat a disease or condition mediated by blockingThe epithelial sodium channel.
Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.COMPUESTOS DERIVADOS DE PIRAZIN-2-CABONIL-IMINO-1,3,8-TRIAZA-ESPIRO-[4.5]-DECAN-SUSTITUIDOS, BLOQUEADORES DEL CANAL DE SODIO EPITELIAL (ENAC)； COMPOSICION FARMACEUTICA QUE LOS INCLUYE； Y SU USO PARA TRATAR UNA ENFERMEDAD O CONDICION MEDIADA POR EL BLOQUEO DEL CANAL DE SODIO EPITELIAL.
