Inhibitors of 17beta-HSD1, 17beta-HSD3 and 17beta-HSD10

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专利权人:

Universite Laval

发明人:

Poirier, Donald,Roy, Jenny,Maltais, Rene

申请号：

AU2012234682

公开号：

AU2012234682A1

申请日:

2012.03.26

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSDl inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSDl and 17β HSD3 that have a spiro-morpholine substituent at C20.

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中国工程科技知识中心

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