ДЗЕ ЮНАЙТЕД СТЭЙТС ОФ АМЕРИКА, ЭЗ РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТЭРИ, ДЕПАРТМЕНТ ОФ ХЕЛТ ЭНД ХЬЮМАН СЕРВИСИЗ (US); ИНК. (US);ГЛОУБИММЬЮН;ГЛОУБИММЬЮН, ИНК. (US)
发明人:
ПАЛЕНА Клаудиа (US),ГО Чжиминь (US),ЭЙПЕЛИАН Дэвид (US),ШЛОМ Джеффри (US)
申请号：
RU2013146324/15
公开号：
RU2013146324A
申请日:
2012.03.19
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of reducing, stopping, reversing, slowing down or preventing the metastatic progression of a malignant tumor in an individual with a malignant tumor that is undergoing metastatic progression, is at risk of metastatic progression, or which is predicted to undergo metastatic progression, of an immunotherapeutic composition comprising: a) a yeast carrier； and b) a cancer antigen containing at least one Brachyury antigen. 2. The method according to claim 1, wherein Brachyury expression is not detected in a malignant tumor of an individual at the time the composition is first administered. The method of claim 1, wherein Brachyury expression is detected in a malignant tumor of an individual at the time the composition is first administered. The method of claim 1, wherein the individual has a stage I.5 malignant tumor. The method according to claim 1, where the individual has a malignant tumor of stage II.6. The method of claim 1, wherein the individual has a stage III.7 malignant tumor. The method of claim 1, wherein the individual has a stage IV.8 malignant tumor. A method for preventing or slowing down the occurrence of a Brachyury-expressing cancer, comprising administering to an individual an immunotherapeutic composition comprising: a) a yeast carrier； and b) a cancer antigen containing at least one Brachyury antigen. 9. The method of claim 8, wherein the cancer is not detected in the individual. The method of claim 9, wherein the individual has a high risk of developing a malignant tumor. The method of claim 8, wherein the individual has a precancerous lesion. The method of claim 8, wherein the individual has a malignant tumor, but in a malignant tumor1. Способ снижения, прекращения, обращения, замедления или профилактики метастатического прогрессирования злокачественной опухоли у индивидуума со злокачественной опухолью, которая претерпевает метастатическое прогрессирование, имеет риск метастатического прогрессирования или которая, по прогнозам, начала п
