The present invention relates to FGFR4 inhibitors having the structure of Formula (I), methods for their preparation and applications. The compounds of the formula (I) series developed in the present invention have high inhibitory action on FGFR4 kinase activity and also very high selectivity, and cancer, especially liver cancer, gastric cancer, prostate cancer, skin cancer, It can be widely used in the manufacture of therapeutic agents for ovarian cancer, lung cancer, breast cancer or colon cancer, and can be expected to be developed as a next-generation FGFR4 inhibitor drug.本発明は、式（Ｉ）構造を有するＦＧＦＲ４阻害剤、その製造方法及び応用に関する。本発明で開発された式（Ｉ）シリーズの化合物はＦＧＦＲ４キナーゼ活性に対して高阻害作用を有するとともに、非常に高い選択性を有し、癌、特に肝臓癌、胃癌、前立腺癌、皮膚癌、卵巣癌、肺癌、乳癌又は結腸癌の治療薬の製造に幅広く使用されることができ、次世代ＦＧＦＲ４阻害剤薬物として開発されることが期待できる。
