The present invention relates to an FGFR4 inhibitor having the structure of formula (I) and a method for producing and using the same. The definition of each substituent in the formula is as described in the description and the claims. The series of compounds of the formula (I) developed in the present invention have a strong inhibitory effect on the activity of FGFR4 kinase and have a very high selectivity, and can be used for cancer, especially prostate cancer, liver cancer, pancreatic gland A new generation of FGFR4 inhibitors that can be widely applied in the manufacture of drugs to treat cancer, esophageal cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, colon cancer, skin cancer, glioblastoma or rhabdomyosarcoma It is expected to be developed as a drug. Embedded image本発明は、式（I）構造を有するFGFR4阻害剤およびその製造方法と使用に関し、式における各置換基の定義は明細書および請求の範囲に記載の通りである。本発明で開発された式（I）の一連の化合物は、FGFR4キナーゼの活性に対して強い阻害作用を有し、かつ非常に高い選択性を有し、癌、特に前立腺癌、肝癌、膵臓腺癌、食道癌、胃癌、肺癌、乳癌、卵巣癌、結腸癌、皮膚癌、神経膠芽細胞腫または横紋筋肉腫を治療する薬物の製造に幅広く応用することができ、新世代のFGFR4阻害剤薬物として開発されることが期待されている。【化１】
