Provided are FGFR4 inhibitors having the structure of formula (I) and methods for their production and use. The compound of the formula (I) has a strong inhibitory action on FGFR4 kinase activity and has a very high selectivity, and is cancerous, particularly liver cancer, stomach cancer, prostate cancer, skin cancer, ovarian cancer, lung cancer, breast cancer or It is widely applied in the manufacture of drugs for treating colon cancer and is expected to be developed as a new generation FGFR4 inhibitor drug.式（Ｉ）の構造を有するＦＧＦＲ４阻害剤並びにその製造方法及び使用を提供する。前記式（Ｉ）系化合物は、ＦＧＦＲ４キナーゼ活性に対して強い阻害作用を示し、かつ非常に高い選択性を示し、癌症、特に肝癌、胃癌、前立腺癌、皮膚癌、卵巣癌、肺癌、乳癌又は結腸癌を治療する薬物の製造に広く適用され、新世代のＦＧＦＲ４阻害剤薬物として開発されることが期待されている。
