SEOUL NATIONAL UNIVERSITY OF TECHNOLOGY CENTER FOR INDUSTRY COLLABORATION
发明人:
NOH, IN SUP,노인섭,JO, SEONG YEUN,조성연,KIM, SU MI,김수미
申请号：
KR1020110091941
公开号：
KR1020130028411A
申请日:
2011.09.09
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A polymer compound and a drug delivery system are provided to be easily manufactured by introducing tris(2-carboxyethyl)phosphine into a polymer side chain, and to be used for a drug delivery system.CONSTITUTION: A polymer compound is coupled to a tris(2-carboxyethyl)phosphine. The polymer compound is a carboxyl group-containing biodegradable polymer compound. The tris(2-carboxylethyl)phosphine forms a combination through chemical reaction with a carboxyl group. A chemical bond between the carboxyl group of the tris(2-carboxyethyl)phosphine and the carboxyl group of the polymer is coupled to the carboxyl group of the polymer compound through a linker. The crosslinked polymer compound is composed of the coupling between the polymer compound and the acryl functional group-containing polymer compound by a Michael type additive reaction.COPYRIGHT KIPO 2013TCEP가 결합된 고분자 화합물 및 이것과 아크릴 작용기를 가지는 고분자 화합물이 마이클 형 첨가반응에 의하여 서로 결합하여 가교화된 가교화 고분자 화합물이 개시된다. 본 발명에 따른 가교화 고분자 화합물은 하이드로젤로 제조되어 약물전달체, 조직공학 지지체, 또는 세포치료제로 사용된다.
