Dirk Henning Lenz;Gary Brian Evans;Olga Vladimirovna Zubkova;Richard Hubert Furneaux;Vern L. Schramm;Peter Charles Tyler
发明人:
Gary Brian Evans,Richard Hubert Furneaux,Dirk Henning Lenz,Vern L. Schramm,Peter Charles Tyler,Olga Vladimirovna Zubkova
申请号：
US12455537
公开号：
US08173662B2
申请日:
2009.06.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
