Industrial Research Limited;Albert Einstein College of Medicine of Yeshiva University
发明人:
Furneaux, Richard Hubert,Schramm, Vern L.,Evans, Gary Brian,Mee, Simon Peter Harold,Zubkova, Olga Vladimirovna,Tyler, Peter Charles
申请号：
AU2006248199
公开号：
AU2006248199B2
申请日:
2006.05.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
