HYND GEORGE U K,MONTANA JOHN GARY U K,FINCH HARRY U K,ARIENZO ROSA U K,AVITABILE WOO BARBARA U K,DOMOSTOJ MATHIAS U K
申请号：
IN3997/DELNP/2010
公开号：
IN298003B
申请日:
2008.12.12
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Compound of formula (I) are are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. Wherein X is -SO2- or *-S02NR3- wherein the bond marked with an asterisk is attached to Ar1； R1 is hydrogen, fluoro, chloro, CN or CF3； R2 is hydrogen, fluoro or chloro； R3 is hydrogen, C1C8alkyl or C3-C7cycloalkyl； Ar1 is phenyl or a 5- or 6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C3- C7Cycloalkyl, -0(C1-C4alkyl) or C1C6alkyl, the latter two groups being optionally substituted by one or more fluoro atoms； and Ar2 is phenyl or 5- or 6-membered heteroaryl group selected from pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C3- C3- C7Cycloalkyl, -0(C1-C4alkyl) or C1C6alkyl, the latter two groups being optionally substituted by one or more fluoro atoms.
