HYND, GEORGE,MONTANA, JOHN GARY,FINCH, HARRY,ARIENZO, ROSA,AVITABILE-WOO, BARBARA,DOMOSTOJ, MATHIAS
申请号：
CA2707785
公开号：
CA2707785C
申请日:
2008.12.12
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compound of formula (I) are are ligands of the CRTH2 receptor, useful interalia for treatment of inflammatoryconditions. Wherein X is -SO2- or *-SO2NR3- wherein the bond marked with anasterisk is attached to Ar1； R1 is hydrogen, fluoro,chloro, CN or CF3； R2 is hydrogen, fluoro or chloro； R3 is hydrogen, C1C8alkylor C3-C7cycloalkyl； Ar1 is phenyl or a 5-- or6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl,thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl,pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl orheteroaryl groups are optionally substituted by one or moresubstituents independently selected from fluoro, chloro, CN, C3- C7cycloalkyl,-O(C1-C4alkyl) or C1C6alkyl, the latter two groupsbeing optionally substituted by one or more fluoro atoms； and Ar is phenyl or5- or 6-membered heteroaryl group selected frompyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl,isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl andpyrazinyl, wherein the phenyl or heteroaryl groups are optionally substitutedby one or more substituents independently selectedfrom fluoro, chloro, CN, C3- C3- C7cycloalkyl, -O(C1-C4alkyl) or C1C6alkyl,the latter two groups being optionally substituted byone or more fluoro atoms.
