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Sulfonyl piperazine derivative substituted at position 3
专利权人:
MSD K.K.
发明人:
NAGASE, TSUYOSHI,SASAKI, TAKAHIDE,TAKAHASHI, TOSHIYUKI
申请号:
ES09709105
公开号:
ES2528129T3
申请日:
2009.02.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof; ** Formula ** in which Z is selected from the group consisting of the following Formulas (II-1), (II-2) and ( II-3) ** Formula ** in which n1, n2 and n3 are 0, 1 or 2, respectively in which, R1 represents C1-6 alkyl, C3-8 cycloalkyl, aryl or heteroaryl, in which the alkyl , the cycloalkyl, aryl or heteroaryl may be substituted with a substituent selected from the group consisting of: hydroxy, cyano, carboxyl, sulfo, halogen, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, alkoxy C1-6, haloalkoxy C1-6, amino (the amino being optionally substituted with between 1 and 2 alkyls, aryls or heteroaryls C1-6), carbamoyl (the carbamoyl being optionally substituted with between 1 and 2 alkyls, aryls or heteroaryls C1- 6), sulfanyl (the sulfanyl being optionally substituted with a C 1-6 alkyl, aryl or heteroaryl), C 1-6 alkylsulfinyl, arylsulfinyl, hete roarylsulfinyl, C1-6 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, sulfamoyl (the sulfamoyl being optionally substituted with between 1 and 2 alkyls, aryl or C1-6 heteroaryls), C1-6 alkylsulfonylamino, arylsulfonylamino, heteroarylsulfonylamino, C1-6 alkylarylcarbonyl, carbonylcarbonyl, carbonyl , C1-6 alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, carbamoylamino (carbamoylamino being optionally substituted with between 1 and 2 alkyls, aryls or C1-6 alkylaryls), C1-6 alkoxycarbonylamino, aryloxycarbonylamino, heteroaryloxycarbonylamino, C1-6 alkylaminocarbonylamino, carbonylaminocarbonylamino, C 1-6 alkylamino, carbonylamino aryl, heteroaryl, aralkyl, heteroaralkyl, aralkyloxy and heteroaralkyloxy; R2 represents phenyl or heteroaryl, wherein the phenyl or heteroaryl may be substituted with a substituent selected from the group consisting of: hydroxy, cyano, carboxyl, sulfo, halogen, C1-6 alkyl, C1-6 haloalkyl, C3 cycloalkyl -8, C1-6 alkoxy, C1-6 haloalkoxy, amino (the amino being optionally substituted with between 1 and
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