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Spirolactam derivatives and uses thereof
专利权人:
H. LUNDBECK A/S
发明人:
ZHOU, HAO,LI, GUIYING,DOLLER, DARIO,MA, GIL
申请号:
ES10827383
公开号:
ES2465994T3
申请日:
2010.10.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (I): ** Formula ** wherein: each of R1 and R2 is independently aryl, heteroaryl, alkyl, cycloalkyl, ketocycloalkyl or heterocyclyl, which is optionally mono, di or tri independently substituted with alkyl, cycloalkyl , alkoxy, hydroxy, halogen, cyano, trifluoroalkyl, amino, acyl, aryl, heteroaryl, heterocyclyl, -C (O) NHR30, -C (O) N (R30) R31, -NHC (O) R30, -N (R30 ) C (O) R31, -NHR30, N (R30) R31 or -OR30; wherein: each of R30 and R31 are independently C1-C6 alkyl or C1-C6 cycloalkyl which is optionally substituted with acyl, halogen, -CN, -NH2, -NH (C1-C3 alkyl), N (C1-C3 alkyl ) 2, C1-C3 alkylheterocyclyl, C1-C3 alkylcarbamate, C (O) NH (C1-C3 alkyl), -C (O) N (C1-C3 alkyl) 2, -NHC (O) -C1-C3 alkyl, -N (C1-C3 alkyl) -C (O) -C1-C3 alkyl, OH or -O- C1-C6 alkyl; and each aryl, heteroaryl, heterocyclyl substituent is optionally substituted with C1-3 alkyl, C3-5 cycloalkyl, C1-3 alkoxy, hydroxy, halogen, cyano, trifluoroalkyl or amino; each of R3, R4, R5 and R6 is independently H, C1-3 alkyl, C3-5 cycloalkyl, halogen or hydroxy; R7 is H; or R1 and R7 taken together with the -C (O) N- to which they are attached form a mono or bicyclic 4-12 membered heterocycloalkyl or heteroaryl, optionally containing 1-3 additional heteroatoms; or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I):**Fórmula** en donde: cada uno de R1 y R2 es independientemente arilo, heteroarilo, alquilo, cicloalquilo, cetocicloalquilo o heterociclilo, que está opcionalmente mono, di o tri sustituido independientemente con alquilo, cicloalquilo, alcoxi, hidroxi, halógeno, ciano, trifluoroalquilo, amino, acilo, arilo, heteroarilo, heterociclilo, -C(O)NHR30, -C(O)N(R30)R31, -NHC(O)R30, -N(R30)C(O)R31, -NHR30, N(R30)R31 o -OR30; en donde: cada uno de R30 y R31 son independientemente alquilo C1-C6 o cicloalquilo C1-C6 que está opcionalmente sustituido con acilo, halógeno, -CN, -NH2, -NH(alquilo C1-C3), N(alquilo C1-C3)2, alquilheterociclilo C1-C3, alquilcarbamato
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