The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.本發明係關於抗-CSF-1R抗體及其結合片段、編碼其之DNA、包含該DNA之宿主細胞及於宿主細胞中表現該抗體或結合片段之方法。本發明亦關於包含該抗體或其結合片段之醫藥組合物及一種以該抗體、結合片段及包含其之組合物於治療中之用途。