The present invention relates to an anti-CSF-1R antibody and a binding fragment thereof, a DNA encoding the same, a host cell containing the DNA, and a method for expressing an antibody or a binding fragment in the host cell. The invention also extends to pharmaceutical compositions comprising antibodies or binding fragments thereof and the use of antibodies, binding fragments and compositions comprising them in treatment.本発明は抗CSF-1R抗体及びその結合断片、それをコードするDNA、前記DNAを含む宿主細胞、並びに宿主細胞で抗体又は結合断片を発現させる方法に関する。本発明は、抗体又はその結合断片を含む医薬組成物並びに処置における抗体、結合断片及びそれを含む組成物の使用にも及ぶ。