BOCK, MARK G.,CHIKKANNA, DINESH,MCCARTHY, CLIVE,MOEBITZ, HENRIK,PANDIT, CHETAN,PODDUTOORI, RAMULU
申请号：
PE0007782012
公开号：
PE13842012A1
申请日:
2010.12.07
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to Heterocyclic sulfonamide compounds of formula (i) where X is n or CH is aryl or heteroaryl r1 R2 is H or alkyl (C1 - C6) R3 is H or alkyl (C1 - C6) optionally replaced with Halogen or hydroxyl R4 and R5 are each h, halogen or alkyl, optionally substituted (C1 - C6) With Halogen, R6 is H or alkyl (C1 - C6) R7 is alkyl (C1 - C6), alquenilo (C2 - C6), alquinilo (C2 - C6)Cycloalkyl, among others. Preferred compounds are: 4.5 - difluoro - [6 - (2-fluoro-4 - Iodine - amino phenyl) - benzo - oxazole - 7 - yl] - ciclopropan - sulfonic acid amide [4,5 - difluoro - 6 - (2 - 4 - fluoro - Iodine - amino phenyl) - 2 - Methyl benzo - - 7 - yl] - oxazole amide acid dimethyl sulfamico [4,5 - difluoro - 6 - (2 - 4 - fluoro - Iodine - amino phenyl) - benzo - oxazole - 7 - il] - amide acid dimethyl sulfamico among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of MEK kinase being useful in the treatment of cancerSE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDA HETEROCICLICOS DE FORMULA (I) DONDE X ES N O CH R1 ES ARILO O HETEROARILO R2 ES H O ALQUILO(C1-C6) R3 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO O HIDROXILO R4 Y R5 SON CADA UNO H, HALOGENO O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO R6 ES H O ALQUILO(C1-C6) R7 ES ALQUILO(C1-C6), ALQUENILO(C2-C6), ALQUINILO(C2-C6), CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [4,5-DIFLUORO-6-(2-FLUORO-4-YODO-FENIL-AMINO)-BENZO-OXAZOL-7-IL]-AMIDA DEL ACIDO CICLOPROPAN-SULFONICO [4,5-DIFLUORO-6-(2-FLUORO-4-YODO-FENIL-AMINO)-2-METIL-BENZO-OXAZOL-7-IL]-AMIDA DEL ACIDO DIMETIL-SULFAMICO [4,5-DIFLUORO-6-(2-FLUORO-4-YODO-FENIL-AMINO)-BENZO-OXAZOL-7-IL]-AMIDA DEL ACIDO DIMETIL-SULFAMICO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA DE MEK SIENDO UTILES EN EL TRATAMIENTO DE CANCER
