STOKES, Stephen,GRAHAM, Christoper John,RAY, Stuart Christopher,STEFANIAK, Emma Jayne
申请号：
ES13703121
公开号：
ES2637340T3
申请日:
2013.01.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: each Z is independently (Alk) n-Rn- (Alk) nX, wherein each Alk is independently alkylene (C1 to C12) or alkenylene (C2 to C12), each of which may be optionally substituted； each n is independently 0 or 1； each R is independently optionally substituted arylene or heteroarylene, or optionally substituted cycloalkylene or heterocycle, -O-, -S-, - (C>； = O) -, - (C>； = S) -, -SO2-, -C ( >； = O) O-, -C (>； = O) NRA-, -C (>； = S) NRA-, -S02NRA-, -NRAC (>； = O) -, -NRASO2- or -NRA- where RA is hydrogen, C1-C6 alkyl, - (C1-C6 alkyl) - (cycloalkyl), (C1-C6 alkyl) - (C1-C6 alkoxy) or C1-C6 alkoxy； each X is independently halogen, -H, -ORA, NRARA, optionally substituted aryl or heteroaryl, or optionally substituted cycloalkyl or heterocycle, CN or C (halogen) aHb, where a is 1, 2 or 3, and b is (3-a )； Y is optionally substituted aryl or heteroaryl, or optionally substituted cycloalkyl or heterocycle； and R1 is H or C1-C6 alkyl, with the proviso that the compound is not N- (5-bromo-4-fluoro-1H-pyrrolo [2,3-b] pyridin-3-yl) -1- ( 4- methoxybenzyl) -1H-pyrazol-4-carboxamide or (R) -1- (5-bromo-3- (1- (4-methoxybenzyl) -1Hpirazol-4-carboxamido) -1H-pyrrolo [2,3- b] tert-butyl pyridin-4-yl) piperidin-3-ylcarbamate.Un compuesto de fórmula I: **Fórmula** o una de sus sales farmacéuticamente aceptables, en donde: cada Z es independientemente (Alk)n-Rn-(Alk)n-X, en donde cada Alk es independientemente alquileno (C1 a C12) o alquenileno (C2 a C12), cada uno de los cuales puede estar opcionalmente sustituido； cada n es independientemente 0 o 1； cada R es independientemente arileno o heteroarileno opcionalmente sustituido, o cicloalquileno o heterociclo opcionalmente sustituido, -O-, -S-, -(C>；=O)-, -(C>；=S)-, -SO2-, -C(>；=O)O-, -C(>；=O)NRA-, -C(>；=S)NRA-, -S02NRA-, -NRAC(>；=O)-, -NRASO2- o -NRA- en donde RA es hidrógeno, alquilo C1-C6 , -(alquil C1-C6)-(cicloalquil), (a
