The present invention is related to a system and method to ensure the reproducibility of the position of the feet and lower parts of the legs, during the Magnetic Resonance Imaging (MRI) studies, to obtain robust quantitative information through the time. The system comprises a device that is inserted into the radiofrequency coils of any MRI equipment. Said device comprises a foot support section, a leg support section and a base adapted to allow that the abovementioned sections be fixed in it. With this device and method, through external and internal markers, quantitative studies of the evolution of pathophysiological phenomena that affect the anatomy and physiology of the feet and lower parts of the legs are performed.