The present invention provides the compound and its pharmaceutical composition that activity of EGFR can be adjusted with what, and the method using these compound treating, ameliorating or preventing illness related with abnormal or imbalance activity of EGFR.本發明提供可用於調節EGFR活性的化合物及其藥物組合物,以及使用這些化合物治療、改善或預防與異常或失調的EGFR活性有關的病症的方法。