Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.本發明提供用於調節受體激酶活性及用於治療、預防或改善由受體激酶所介導之疾病或病症之一或多種症狀的化合物、組合物及方法。