LIN, CHIAN YUH,林千玉,林千玉,CHEN, CHUN REN,陈俊仁,陳俊仁,LIAO, WAN TESN,廖婉岑,廖婉岑,TZEN, JASON T. C.,曾志正,曾志正,CHANG, MING TSUNG,张铭聪,張銘聰
申请号：
TW102121501
公开号：
TW201500057A
申请日:
2013.06.18
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention relates to an artificial oil body and a method for manufacturing the same. Primarily, the artificial oil body comprises a mixed liquid of non-triglyceride oils, phospholipids, calcium proteins of the oil body and sodium phosphate buffer solution. The mixed liquid is oscillated by an ultrasonic oscillator and soaked with ice. Then the operations of the oscillation and the soaking with ice are repeated. Thereby the artificial oil body is dispersed in an aqueous phase. In particular, a composite solvent is used as oil. It can design the content of the formula for a specific hydrophobic drug to improve its solubility. Furthermore, the particle size of the new type artificial oil body can be smaller and more stable than the droplet size of the natural oil body or the conventional artificial oil body. Moreover, non-DOGP phospholipids can also be used to manufacture the artificial oil body. Therefore, the artificial oil body has the broader formulation flexibility to meet the requirement of portable transfer for various compounds.本發明係有關於一種人造油體及其製造方法,此人造油體主要係將包括有非三酸甘油酯油類、磷脂質、油體鈣蛋白,以及磷酸鈉緩衝溶液之混合液體,以超音波震盪器震盪後,再將混合液體冰浴,並重複上述震盪冰浴作業;藉此,使人造油體分散於水相中,尤其是以複合溶劑為油類,能針對特定疏水性藥物而設計配方內容,提高其溶解度,且使新型人造油體粒徑能比天然油體或傳統人造油體的液滴粒徑更小,且更穩定;此外,非DOGP磷脂質亦可製造人造油體,故使人造油體具備較廣大的配方彈性,更可應付各式各樣化合物的攜帶傳遞需求。(S1)‧‧‧步驟一(S2)‧‧‧步驟二(S3)‧‧‧步驟三
