Proteolysis Targeting Chimera Compounds and Methods of Preparing and Using Same

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专利权人:

YALE UNIVERSITY

发明人:

Craig CREWS,Momar TOURE,Eunhwa KO,Saul JAIME-FIGUEROA

申请号：

US16848290

公开号：

US20200325130A1

申请日:

2020.04.14

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.

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中国工程科技知识中心

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http://www.ckcest.cn/home/