COMPOSES CHIMERES DE CIBLAGE DE PROTEOLYSE ET PROCEDES DE PREPARATION ET D'UTILISATION DE CEUX-CI

• 收藏
• 分享

专利权人:

YALE UNIVERSITY

发明人:

CREWS, CRAIG,TOURE, MOMAR,KO, EUNHWA,JAIME-FIGUEROA, SAUL

申请号：

CA3002709

公开号：

CA3002709A1

申请日:

2016.11.02

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. The methods of the present invention comprise administering to the subject an pharmaceutically effective amount of at least one compound of the invention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/